C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61K 48/00 (2006.01) A61P 25/00 (2006.01) C07K 16/44 (2006.01) C07K 19/00 (2006.01) C12N 7/00 (2006.01) C12N 15/11 (2006.01) C12P 21/02 (2006.01) C12Q 1/70 (2006.01)
Patent
CA 2534899
DNAs encoding polypeptides comprising random amino acid sequences are synthesized and integrated into a phage library. Then a polypeptide having brain disposition activity is screened. As a result, a plural number of polypeptides having brain disposition activity are obtained. These polypeptides contain a sequence in common. Thus, an amino acid motif sequence participating in the brain disposition activity is successfully identified.
L'invention concerne des polypeptides codant des ADN, qui comprennent des séquences d'aminoacide aléatoires. Lesdits polypeptides sont synthétisés et intégrés dans une bibliothèque de lysotypes. Un polypeptide agissant sur des prédispositions à des pathologies cérébrales est ensuite sélectionné, ce qui a pour effet d'obtenir un nombre multiple de polypeptides agissant sur des prédispositions à des pathologies cérébrales. Ces polypeptides contiennent une séquence en commun. L'invention permet d'identifier efficacement une séquence de motif d'aminoacide participant à l'activité de disposition cérébrale.
Actgen Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Tissue Targeting Japan Inc.
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