Polypeptides having neutrophil stimulating activity

Details Polypeptides having neutrophil stimulating activity Polypeptides having neutrophil stimulating activity

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/80 (2006.01) C07K 16/18 (2006.01) C07K 16/40 (2006.01) C12N 9/02 (2006.01) C12N 15/19 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) C07K 14/52 (2006.01)

Patent

CA 2402238

A factor capable of attracting and activating neutrophils which might be prepared by normal cells. A polypeptide having an activity of stimulating neutrophils is isolated from an extract obtained from healthy swine heart. Namely, provision is made of: (a) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:1; (b) a polypeptide comprising an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO:1 by deletion, substitution or insertion of one to several amino acids and having the activity of stimulating neutrophils; and (c) a polypeptide comprising an amino acid sequence which is biologically equivalent to the amino acid sequence of the polypeptide (a) or (b) as described above.

Cette invention concerne un facteur capable d'attirer et de stimuler des neutrophiles susceptibles d'être produits par des cellules normales. On isole un polypeptide capable de stimuler les neutrophiles à partir d'un extrait de coeur de porc sain. Plus précisément, l'invention concerne : (a) un polypeptide renfermant la séquence d'acides aminés représentée par SEQ ID NO :1 ; (b) un polypeptide renfermant une séquence d'acides aminés tirée de la séquence d'acides aminés SEQ ID NO :1 par délétion, substitution ou insertion d'un ou de plusieurs acides aminés et dont l'activité stimule les neutrophiles ; et (c) un polypeptide renfermant une séquence d'acides aminés équivalente au plan biologique à la séquence d'acides aminés des polypeptides (a) ou (b) susmentionnés.

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