C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/56 (2006.01) A61K 45/00 (2006.01) A61P 31/10 (2006.01) C07K 14/37 (2006.01) C07K 14/40 (2006.01) C12N 9/24 (2006.01) C12N 15/31 (2006.01) C12N 15/63 (2006.01) C12Q 1/02 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2479474
The present invention relates to a purified polypeptide, and the polynucleotide encoding same, naturally involved in fungal biofilm formation. More specifically, the polypeptide of the present invention is overexpressed in a fungus during biofilm growth compared to planktonic growth. The present invention also relates to a method for identifying compounds that inhibit such polypeptides as well as for identifying compounds that affect biofilm formation; and use of such compounds in compositions and methods for the prevention and the treatment of biofilm forming fungus-associated diseases, such as those caused by Candida albicans.
Cottier Fabien
D'enfert Christophe Didier
Garcia-Sanchez Susana
Ghigo Jean-Marc
Iraqui Ismaiel
Institut Pasteur
Robic
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