Polypeptides involved in neuronal regeneration-associated...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/47 (2006.01)

Patent

CA 2704314

The present invention relates to methods for promoting regeneration response of peripheral and central nervous systems in mammals in need of such biological effects. The methods comprise altering the activity or steady state level of specific transcription factors that control regeneration of injured or degenerated neuronal cells. Preferably the activity or steady state level of specific transcription factors is altered by introducing nucleic acids to increase or decrease expressing of these transcription factors. These are useful to a patient suffering from neurodegenerative disorders.

La présente invention porte sur des procédés pour favoriser une réponse de régénérescence des systèmes nerveux périphérique et central dans des mammifères nécessitant de tels effets biologiques. Le procédé comprend la modification de l'activité ou du taux à l'état stable de facteurs de transcription spécifiques qui contrôlent la régénérescence de cellules neuronales lésées ou dégénérées. De préférence, l'activité ou le taux à l'état stable de facteurs de transcription spécifiques est modifié par introduction d'acides nucléiques pour augmenter ou diminuer l'expression de ces facteurs de transcription. Ils sont utiles à un patient souffrant de troubles neurodégénératifs.

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