Polypeptides involved in the neuroregeneration-promoting...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/85 (2006.01) C12N 5/079 (2010.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/71 (2006.01) C07K 14/81 (2006.01) C12N 15/12 (2006.01) C12N 15/15 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2726945

The present invention relates to methods for promoting regeneration response of primary olfactory nervous system m mammals m need of such biological effects. The methods comprise altering the activity or steady state level of a polypeptide as defined herein that control regeneration of injured or degenerated neuronal cells. Preferably the activity or steady state level of said polypeptide is altered by introducing nucleic acids to increase expressing of at least one of these polypeptides. These are useful in or suffering from neurotraumatic injury such as spinal cord injury.

La présente invention concerne des procédés de promotion de la réponse de régénération du système nerveux olfactif primaire chez des mammifères nécessitant ces effets biologiques. Les procédés comprennent la modification du niveau dactivité ou d'un niveau stable dun polypeptide tel que défini dans le présent document qui contrôle la régénération de cellules neuronales endommagées ou dégénérées. Le niveau dactivité ou le niveau stable dudit polypeptide est de préférence modifié par introduction dacides nucléiques pour faire augmenter lexpression dau moins un de ces polypeptides. Ceux-ci sont utiles chez les patients souffrant dune lésion neurotraumatique telle quune lésion de la moelle épinière.

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