Polypeptides modified by protein trans-splicing technology

Details Polypeptides modified by protein trans-splicing technology Polypeptides modified by protein trans-splicing technology

C - Chemistry, Metallurgy

07

K

C07K 14/195 (2006.01) C07K 17/00 (2006.01) C07K 19/00 (2006.01) C08G 65/329 (2006.01) C12N 9/00 (2006.01) C12N 15/52 (2006.01) C12N 15/62 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2707979

The present invention relates to a method of preparing modified polypeptides, by linking a target polypeptide to a carrier molecule that is designed to bear one or more water-soluble polymer molecules, via protein trans-splicing. The polymer molecules can be attached to the carrier molecule either before or after ligation to the target polypeptide. Novel protein trans-splicing elements (known as "split inteins") and trans-splicing partners are also provided.

La présente invention porte sur un procédé de préparation de polypeptides modifiés, par liaison d'un polypeptide cible à une molécule support qui est mise au point pour porter une ou plusieurs molécules polymères solubles dans l'eau, par transépissage de protéines. Les molécules polymères peuvent être attachées à la molécule support soit avant, soit après ligature au polypeptide cible. L'invention porte également sur de nouveaux éléments de transépissage de protéines (connus comme étant des = intéines fragmentées =) et sur des partenaires de transépissage.

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