Polypeptides useful as blockers of calcium channels

Details Polypeptides useful as blockers of calcium channels Polypeptides useful as blockers of calcium channels

C - Chemistry, Metallurgy

07

K

167/5.1, 530/15.

C07K 14/435 (2006.01) A01N 37/18 (2006.01) A01N 63/02 (2006.01) A61K 38/17 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2026418

This invention relates to a polypeptide found to be present in the venom of the Agelenopsis aperta spider and to polypeptides having substantially the same amino acid sequence and substantially the same activity as said polypeptide. The polypeptides of this invention and the salts thereof block calcium channels in cells of various organisms and are useful in blocking said calcium channels in cells, per se; in the treatment of calcium channel mediated diseases and conditions; and in the control of invertebrate pests. This inven- tion also relates to compositions comprising said polypeptides and salts thereof.

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