Polypeptides useful as immunotherapeutic agents and methods...

Details Polypeptides useful as immunotherapeutic agents and methods... Polypeptides useful as immunotherapeutic agents and methods...

C - Chemistry, Metallurgy

07

K

C07K 14/025 (2006.01) A61K 39/12 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2211995

Fusion polypeptides and aggregates of polypeptides comprising papillomavirus-derived antigens, and compositions thereof and their use e.g. with adjuvants for immunogenic and vaccine purposes in eliciting e.g. HPV-specific immune responses. The polypeptides can be purified to result in aggregates which when in solution or dispersion can pass through a sterilisation filter, and in amorphous aggregates. An example of such a polypeptide is a fusion protein of human papillomavirus proteins L2 and E7.

Cette invention se rapporte à des polypeptides de fusion et à des agrégats de polypeptides, comprenant des antigènes dérivés du papillomavirus, et à des compositions de ceux-ci et à leur utilisation par exemple avec des adjuvants destinés à servir d'agents immunogènes et de vaccins dans le but de déclencher des réponses immunitaires spécifiques des papillomavirus humains. Ces polypeptides peuvent être purifier pour produire des agrégats, qui, en solution ou en dispersion, peuvent traverser un filtre de stérilisation, et pour produire des agrégats amorphes. Un exemple d'un tel polypeptide est une protéine de fusion des protéines L2 et E7 du papillomavirus humain.

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