C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) A61K 39/395 (2006.01) C07K 1/16 (2006.01) C12P 21/00 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2666308
The invention provides a polypeptide containing at least one IgG Fc region, wherein said at least one IgG Fc region is glycosylated with at least one galactose moiety connected to a respective terminal sialic acid moiety by a .alpha. 2, 6 linkage, and wherein said polypeptide having a higher anti-inflammatory activity as compared to an unpurified antibody.
L'invention concerne un polypeptide contenant au moins une région IgG Fc, ladite région IgG Fc étant glycosylée avec au moins une fonction galactose reliée à une fonction acide sialique terminale respective par une liaison .alpha. 2, 6, et ledit polypeptide ayant une activité antiinflammatoire accrue en comparaison d'un anticorps non purifié.
Kaneko Yoshikatsu
Nimmerjahn Falk
Ravetch Jeffrey V.
Moffat & Co.
The Rockefeller University
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