Polypeptides with fibronectin binding sites as modulators...

Details Polypeptides with fibronectin binding sites as modulators... Polypeptides with fibronectin binding sites as modulators...

C - Chemistry, Metallurgy

07

K

C07K 14/78 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2129115

2129115 9315203 PCTABS00024 The present invention provides fibronectin self-assembly sites. The invention provides a set of polypeptides derived from the first type III repeat of fibronectin which contain a fibronectin-fibronectin binding site. These polypeptides have been used to obtain a second set of polypeptides derived from the C-terminal type I repeats which contain a second fibronectin-fibronectin binding site which interacts with the first type III repeat of fibronectin. These polypeptides are capable of inhibiting fibronectin matrix assembly by interfering with fibronectin-fibronectin binding. These polypeptides are also capable of enhancing fibronectin matrix assembly and inducing disulfide cross-linking of fibronectin molecules in vitro. In addition, these polypeptides are capable of inhibiting migration of tumor cells. The polypeptides of the present invention have a number of related uses as well.

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