Polypeptoid pulmonary surfactants

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/00 (2006.01) A01N 37/18 (2006.01) A61K 38/17 (2006.01) C07K 2/00 (2006.01) C07K 14/785 (2006.01)

Patent

CA 2399757

The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including for the treatment of respiratory distress of the lungs. The spreading agents are sequence-specific oligomers, including retrosequence-specific oligomers, based on a peptide backbone, that are designed as analogs of surfactant protein-B or surfactant protein-C.

L'invention concerne des agents d'étalement basés sur des oligomères spécifiques à la séquence qui comprennent un peptoïde, une chimère peptide-peptoïde, un rétropeptoïde ou une chimère rétro(peptide-peptoïde) ainsi que des procédés pour les utiliser, y compris dans le traitement des dommages subis par les poumons. Les agents d'étalement sont des oligomères spécifiques à la séquence y compris les oligomères spécifiques à la rétroséquence, basés sur un squelette de peptide, conçus comme des analogues de protéines B de surfactant ou de protéines C de surfactant.

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