Polyphenol coxib combinations and methods

Details Polyphenol coxib combinations and methods Polyphenol coxib combinations and methods

A - Human Necessities

61

K

A61K 31/415 (2006.01) A61K 31/353 (2006.01) A61K 31/42 (2006.01) A61K 36/82 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2600276

Contemplated compositions and methods utilize a combination of a polyphenol and a non-polyphenol cyclooxygenase-2 inhibitor. Preferably, the compositions are pharmaceutical and/or nutraceutical compositions and formulated in a dosage form and amount such that the polyphenol and the non-polyphenol cyclooxygenase-2 inhibitor are effective to reduce tumor incidence and/or multiplicity. In preferred aspects, the polyphenol is epigallocatechin gallate, epigallocatechin, epicatechin gallate, epicatechin, and/or a mixture of polyphenols isolated from a plant (e.g., polyphenon E), and the cyclooxygenase-2 inhibitor is rofecoxib, celecoxib, and/or valdecoxib.

L'invention concerne des compositions et des méthodes mettant en oeuvre une combinaison d'un polyphénol et d'un inhibiteur de cyclooxygénase-2 non polyphénol. Ces compositions sont de préférence des compositions pharmaceutiques et/ou nutraceutiques, et elles sont préparées sous forme dosifiée et dans une quantité telle que le polyphénol et l'inhibiteur de cyclooxygénase-2 non polyphénol sont efficaces dans la réduction de l'incidence et/ou de la multiplicité tumorale. Dans des aspects préférés, le polyphénol est un gallate d'épigallocatéchine, de l'épigallocatéchine, un gallate d'épicatéchine, de l'épicatéchine, et/ou un mélange de polyphénols isolés à partir d'une plante (Polyphenon E, par exemple), et l'inhibiteur de cyclooxygénase-2 est du rofécoxib, du célécoxib et/ou du valdécoxib.

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