Polyribonucleotides capable of promoting the genesis of...

C - Chemistry – Metallurgy – 12 – P

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C12P 19/30 (2006.01) C07H 21/00 (2006.01) C07H 21/02 (2006.01) C12P 19/34 (2006.01)

Patent

CA 1093000

ABSTRACT The invention relates to new medicaments useful for the treatment of leucocyte and platelet deficiencies, which medicaments are polyribonucleotides prepared by degradation of the ribosomic ribonucleic acids extracted from micro-organisms or from animal organs and are formed of simple chains or "RN fragments" comprising about 20 to 80 ribonucleotide units, the overall ratio of purine base (G + A) to pyrimidine bases (C + U) being between 1.0 and 2.5. The invention also relates to a process for the preparation of these polyribonucleotides by scission of the ribosomic ribonucleic acids extracted from suitable micro-organisms, by means of a ribonuclease or of a chemical reagent such as an alkali metal base.

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