Polysaccharide gel composition

C - Chemistry – Metallurgy – 08 – B

Patent

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Details

C08B 37/00 (2006.01) C08B 37/08 (2006.01) C08J 3/075 (2006.01) C08L 5/08 (2006.01)

Patent

CA 2226488

The present invention provides a process for preparing a cross-linked biocompatible polysaccharide gel composition, which comprises: forming an aqueous solution of a water soluble, cross-linkable polysaccharide; initiating a cross-linking of said polysaccharide in the presence of a polyfunctional cross-linking agent therefor, sterically hindering the cross-linking reaction from being terminated before gelation occurs, an activated polysaccharide being obtained; and reintroducing sterically unhindered conditions for said activated polysaccharide so as to continue the cross-linking thereof to a viscoelastic gel. The invention also provides a gel composition obtainable by such a process as well as gel compositions for different medical uses.

L'invention se rapporte à un procédé d'élaboration d'une composition de gel à base de polysaccharide biocompatible réticulé, qui consiste: à constituer une solution acqueuse de polysaccharide réticulable hydrosoluble; à entamer une réticulation de ce polysaccharide en présence d'un agent de réticulation polyvalent; à faire en sorte, par empêchement stérique, que la réaction de réticulation ne s'achève pas avant la gélification, ce qui permet d'obtenir un polysaccharide; et à rétablir des conditions sans empêchement stérique pour le polysaccharide activé résultant afin que la réticulation de celui-ci se poursuive jusqu'au stade d'un gel viscoélastique. On décrit par ailleurs une composition de gel susceptible d'être élaborée au moyen d'un tel procédé, ainsi que des compositions de gel se prêtant à différentes utilisations médicales.

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