Polysaccharide-protein conjugates

C - Chemistry – Metallurgy – 07 – K

Patent

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167/129, 530/17.

C07K 17/02 (2006.01) A61K 39/112 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01) A61K 47/48 (2006.01)

Patent

CA 1336308

Vi capsular polysaccharides conjugated to toxin-dependent proteins can be used to enhance antibody response and to convert T-dependent properties to the Vi capsular polysaccharide. A heterobifunctional crosslinking agent can be used to bind thiol derivatives of the Vi capsular polysaccharides to the proteins, such as diphtheria, tetanus toxoids, cholera toxin and Haemophilus influenzae.

582233

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