Polysaccharide vaccine for staphylococcal infections

Details Polysaccharide vaccine for staphylococcal infections Polysaccharide vaccine for staphylococcal infections

A - Human Necessities

61

K

A61K 39/085 (2006.01) C07H 3/06 (2006.01) C07H 5/06 (2006.01) C07H 11/00 (2006.01) C07H 13/12 (2006.01) C08B 37/00 (2006.01)

Patent

CA 2333931

The invention relates to compositions of the capsular polysaccharide/adhesin (PS/A) of staphylococci. The PS/A may be isolated or synthesized and includes various modifications to the structure of native PS/A based on the chemical characterization of PS/A. The invention also relates to the use of the PS/A as a vaccine for inducing active immunity to infections caused by Staphylococcus aureus, S. epidermidis, other related coagulase-negative staphylococci and organisms carrying the ica (intracellular adhesin) locus, and to the use of antibodies directed to PS/A for inducing passive immunity to the same class of infections.

L'invention concerne des compositions de polysaccharide capsulaire/adhésine (PS/A) de staphylocoques. Le PS/A peut être isolé et synthétisé et présente diverse modifications de la structure du PS/A natif en fonction de la caractérisation chimique du PS/A. L'invention concerne également l'utilisation de PS/A comme vaccin pour induire une immunité active contre les infections provoquées par les staphylocoques dorés, par S. epidermidis, par d'autres staphylocoques apparentés négatifs quant à la coagulase et d'autres organismes supportant le foyer d'adhésine intracellulaire. L'invention traite également de l'utilisation d'anticorps concernés par PS/A pour induire une immunité passive pour la même classe d'infections.

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