A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/085 (2006.01) A61K 31/715 (2006.01) A61K 38/00 (2006.01) A61K 39/02 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) A61P 31/04 (2006.01) C07K 16/12 (2006.01) C08B 37/00 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2501077
The invention relates to compositions of a deacetylated poly N-acetylated glucosamine (dPNAG) of Staphylococci. The dPNAG may be isolated from natural sources or synthesized de novo.The invention also relates to the use of dPNAG as a vaccine for inducing active immunity to infections caused by Staphylococcus aureus, S. epidermidis, other related coagulase-negative or coagulase-positive Staphylococci, and other organisms carrying the ica (intracellular adhesion) locus. The invention further provides methods of use for antibodies directed to dPNAG, particularly for inducing passive immunity to the same class of infections.
L'invention se rapporte aux compositions à base de glucosamine poly-N-acétylée déacetylée (dPNAG) des Staphylococci. La dPNAG peut être isolée à partir de sources naturelles ou synthétisée de novo. L'invention concerne aussi l'utilisation de la dPNAG en tant que vaccin pour induire une immunité active aux infections causées par Staphylococcus aureus, S. epidermidis, d'autres organismes liés aux Staphylococci à coagulase négative ou à coagulase positive et d'autres organismes à locus ica (d'adhérence intracellulaire). L'invention concerne aussi des procédés destinés à l'utilisation d'anticorps dirigés sur la dPNAG, notamment pour induire l'immunité passive à la même classe d'infections.
Maira-Litran Tomas
Pier Gerald B.
Brigham And Women's Hospital Inc.
Smart & Biggar
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