Polysubstituted 2-aryl-6-phenyl-imidazo[l,2-a] pyridine...

C - Chemistry – Metallurgy – 07 – D

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C07D 213/28 (2006.01) A61K 31/437 (2006.01) A61P 19/00 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07D 233/56 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2719125

Compounds of Formula (I)  (I), wherein: R1 is: a phenyl group or a naphthyl group, both groups capable of being optionally substituted; X is 1 to 4 substituents, identical to or different from each other and selected from hydrogen, halogen, (C1-C10)alkyl, halo(C1-C10)alkyl, (C1-C10)alcoxy, NRaRb, cyano, or nitro; R, in positions 3, 5, 7, or 8 of imidazo[1,2-a]pyridine, is 1 to 4 substituents, identical to or different from each other; R2 and R3, independently of each other, represent a hydrogen atom or an optionally substituted (C1-C10)alkyl group; an optionally substituted aryl group; R2 and X may form, together with the carbon atoms carrying them, a carbon ring of 5 to 7 carbon atoms; and R4 is a hydrogen atom, an optionally substituted (C1-C10)alkyl group, or an aryl group optionally substituted by one or a plurality of substituents. The invention is used in therapy and in methods of synthesis.

Composés de formule (I) dans laquelle : R1 représente : un groupe phényle ou un groupe naphthyle, ces deux groupes pouvant éventuellement être substitués; X représente de 1 à 4 substituants identiques ou différents l'un de l'autre choisi parmi hydrogène, halogène, (C1-C10)alkyle, halo(C1-C10)alkyle, (C1- C10)alcoxy, NRaRb, cyano, nitro; R représente en position 3,5,7,8 de l'imidazo[1,2-a]pyridine de 1 à 4 substituants identiques ou différents l'un de l'autre; R2 et R3 représentent, indépendamment l'un de l'autre, un atome d'hydrogène, un groupe (C1-C10)alkyle éventuellement substitué; un groupe aryle éventuellement substitué; R2 et X peuvent former ensemble avec les atomes de carbone qui les portent un cycle carboné de 5 à 7 atomes de carbone; R4 représente : un atome d'hydrogène, un groupe (C1- C10)alkyle éventuellement substitué, ou un groupe aryle éventuellement substitué par un ou plusieurs substituants. Utilisation en thérapeutique et procédé de synthèse.

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