Polysulfone hollow fiber semipermeable membrane

Details Polysulfone hollow fiber semipermeable membrane Polysulfone hollow fiber semipermeable membrane

B - Operations, Transporting

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D

B01D 71/68 (2006.01) A61M 1/18 (2006.01) B01D 63/02 (2006.01) B01D 65/02 (2006.01) B01D 67/00 (2006.01) B01D 69/02 (2006.01) B01D 69/08 (2006.01)

Patent

CA 2180222

Respective hollow fiber membranes suitable for use in removing undesired contaminants from blood, in particular in an artificial kidney, have: (1) per membrane area of 1.6 m2, in vitro clearances for urea and phosphorus respectively of >= 195, and >= 180, ml/min, a .beta.2-microglobulin clearance >= 44 ml/min and an albumin permeability <= 0.5%; (2) an albumin permeability <= 1.5% and an overall mass transfer coefficient Ko >= 0.0012 cm/min; and (3) a vitamin B12 dialyzance of >= 135 ml/min and an albumin permeability <= 3%. The membranes can be prepared by spinning hollow fibers from a spinning solution comprising a polysulfone, a hydrophilic polymer, a solvent and water, the spinning solution having a viscosity x at 30°C of 25-130 poise and a quantity y % of water given by: -0.01× + 1.45 <= y <= -0.01× + 2.25. The membranes can be incorporated into a hemodialyzer module by a method in which they are preimpregnated with a wetting agent, thereafter kept separate from one another by spacers and then inserted in the module.

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