Polyunsaturated fatty acid derivatives and their use

C - Chemistry – Metallurgy – 07 – F

Patent

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Details

C07F 9/09 (2006.01) A61K 31/661 (2006.01) A61P 35/00 (2006.01) A61K 31/198 (2006.01) C07C 229/06 (2006.01)

Patent

CA 2358436

Novel amides are disclosed, in particular amides of the all-trans-retinoic acid or 13-cis-retinoic acid and arachidonic acid and docosahexaenoic acid and eicosapentaenoic acid or linoleic acid with 2- aminoethanol, alpha-L-serine, alpha-L-threonine, alpha-L-tyrosine containing phosphate groups. Further, the present invention discloses the synthesis and use of these compounds, in particular their pharmaceutical application.

L'invention concerne de nouveaux amides, en particulier des amides de l'acide all-trans-rétinoïque ou de l'acide 13-cis-rétinoïque, ou de l'acide arachidonique, ou de l'acide docosahexanoïque, ou de l'acide eicosapentanoïque ou de l'acide linoléïque pourvu de 2-aminoéthanol, alpha-L-sérine, alpha-L-thréonine, alpha-L-tyrosine, et contenant des groupes phosphate. L'invention concerne également la synthèse et l'utilisation de ces composés, en particulier leur application pharmaceutique.

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