C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 57/03 (2006.01) A61K 31/19 (2006.01) A61K 31/22 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) C07C 69/587 (2006.01)
Patent
CA 2760877
The present disclosure relates to lipid compounds of the general formula (I): R1-O-C(R2)(R3) -X (I) wherein R1 is a C10-C22 alkyl group, a C10-C22 alkenyl group having 1-6 double bonds, or a C10-C22 alkynyl group having 1-6 triple bonds; R2 and R3 are the same or different and may be chosen from different substituents; and X is a carboxylic acid or a derivative thereof, such as a carboxylic ester, a carboxylic anhydride, a phospholipid, triglyceride, or a carboxamide; or a pharmaceutically acceptable salt, solvate, solvate of such salt or a prodrug thereof. The present disclosure also relates to pharmaceutical compositions and lipid compositions comprising at least one compound according to the present disclosure, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to the cardiovascular, metabolic, and inflammatory disease area.
La présente invention concerne des composés lipidiques de la formule générale (I): R1-O-C(R2)(R3) -X (I) dans laquelle R1 est un groupe alkyle C10-C22, un groupe alcényle C10-C22 ayant 1 à 6 doubles liaisons, ou un groupe alkynyle C10-C22 ayant 1 à 6 triples liaisons; R2 et R3 sont identiques ou différents et peuvent être choisis parmi différents substituants; et X est un acide carboxylique ou un dérivé de celui-ci, tel qu'un ester carboxylique, un anhydride carboxylique, un phospholipide, un triglycéride ou un carboxamide; ou un sel pharmaceutiquement acceptable, un solvate, un solvate de ce sel et un promédicament de celui-ci. La présente invention concerne également des compositions pharmaceutiques et des compositions lipidiques comprenant au moins un composé de cette invention, ainsi que des composés destinés à être utilisés comme médicaments ou en thérapie, en particulier dans le traitement de maladies relatives au domaine des maladies cardio-vasculaires, métaboliques et inflammatoires.
Braendvang Morten
Holmeide Anne Kristin
Hovland Ragnar
Skjaeret Tore
Blake Cassels & Graydon Llp
Pronova Biopharma Norge As
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