Polyvinyl alcohol-based magnetic polymer particles, methods...

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H01F 1/44 (2006.01) B03C 1/01 (2006.01) C07K 1/14 (2006.01) C07K 16/26 (2006.01) C08F 261/04 (2006.01) C08J 3/14 (2006.01) C08J 3/16 (2006.01) C08K 3/22 (2006.01) C08K 9/08 (2006.01) C08L 51/00 (2006.01) C12N 15/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/543 (2006.01) G01N 33/546 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2227608

The invention relates to magnetic, spherical PVAL particles produced through suspension of a polymer phase containing magnetic colloids in a vegetable oil phase containing a special emulsifier mixture. Particles with a particles size of 1-8 µm are obtained which can chemically bind ligands. The carriers can be used to isolate and detect biomolecules, cells, antibodies and nucleic acids.

L'invention concerne des supports magnétiques en alcool de polyvinyle (PVAL) se présentant sous forme de perles, obtenus par suspension d'une phase polymère contenant des colloïdes magnétiques, dans une phase organique contenant un mélange émulsifiant spécial. On obtient des particules d'une grosseur de grain comprise entre 1 et 8 mu m, permettant de lier chimiquement des ligands. Ces supports s'utilisent pour isoler et détecter des biomolécules, des cellules, des anticorps et des acides nucléiques.

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