Poorly water-soluble drug-containing solid formulation

Details Poorly water-soluble drug-containing solid formulation Poorly water-soluble drug-containing solid formulation

A - Human Necessities

61

K

A61K 31/435 (2006.01) A61K 9/32 (2006.01) A61K 47/04 (2006.01) A61P 1/10 (2006.01)

Patent

CA 2558219

Although bisacodyl has been coated with various coatings so as to be released in an area ranging from the lower part of the small intestine to the large intestine, it is less apt to sufficiently produce its effect because of its poor solubility. Furthermore, it has been necessary to incorporate the drug in a larger amount. No technique has been known in which bisacodyl and dioctylsodium sulfosuccinate are simultaneously released in an area ranging from the lower part of the small intestine to the large intestine. The solid pharmaceutical preparation is characterized in that a core particle comprising a sparingly water-soluble drug and dioctylsodium sulfosuccinate has been coated with an enteric coating so as to release the drug in an area ranging from the lower part of the small intestine to the large intestine. It can be an excellent medicine.

Bien que le bisacodyl ait été revêtu de différents enduits de façon à pouvoir être libéré dans une zone comprise entre la partie inférieure de l'intestin grêle et le gros intestin, il est moins apte à produire suffisamment d'effet à cause de la faible solubilité. De plus, il a été nécessaire d'incorporer le médicament en grande quantité. On ne connaît pas de technique qui permettent au bisacodyl et au sulfosuccinate de dioctyle et de sodium d'être libérés dans une zone comprise entre la partie inférieure de l'intestin grêle et le gros intestin. La préparation pharmaceutique solide est caractérisée par le fait qu'une particule noyau comprenant un médicament modérément hydrosoluble et le sulfosuccinate de dioctyle a été revêtu avec un revêtement gastro-résistant de façon à libérer le médicament dans une région comprise entre la partie inférieure de l'intestin grêle et le gros intestin. Cela peut être un excellent médicament.

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