Population based assessments and means to rank the relative...

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/02 (2006.01) C12N 9/56 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2476790

The present invention provides means to assess immune response profiles of populations. In particular, the present invention provides means to qualitatively assess the immune response of human populations wherein the immune response directed against any protein of interest is analyzed. The present invention further provides means to rank proteins based on their relative immunogenicity. In addition, the present invention provides means to create proteins with reduced immunogenicity for use in various applications.

La présente invention concerne des moyens destinés à évaluer des profils de réponse immunitaire de populations. Plus particulièrement, la présente invention concerne des moyens destinés à évaluer qualitativement la réponse immunitaire de populations humaines, cette réponse immunitaire dirigée contre une protéine d'intérêt quelconque étant analysée. La présente invention concerne également des moyens destinés à classer des protéines sur la base de leur immunogénicité relative. En outre, la présente invention se rapporte à des moyens permettant de créer des protéines présentant une immunogénicité réduite en vue d'une utilisation dans diverses applications.

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