Porcine adeno-associated viruses

Details Porcine adeno-associated viruses Porcine adeno-associated viruses

C - Chemistry, Metallurgy

12

N

C12N 7/00 (2006.01) A61K 35/76 (2006.01) A61K 39/00 (2006.01) A61K 39/23 (2006.01) A61K 48/00 (2006.01) C07K 14/015 (2006.01) C12N 7/01 (2006.01) C12N 15/35 (2006.01) C12N 15/864 (2006.01)

Patent

CA 2698011

Porcine tissues were screened for the presence of Adeno-Associated Viruses (AAV). Several AAV sequences were isolated from various porcine tissues, and BLAST analysis confirmed high to low homology with known AAV sequences of different origin. Sequence analysis confirmed the isolation of at least three novel porcine AAV isolates which we named AAVpo1, -po2, and -po3. Novel AAVs derived from porcine tissues may significantly contribute to the generation of new preventive or curative clinical modalities acceptable for human use.

Des tissus porcins ont été criblés pour déterminer la présence de virus adéno-associés (AAV). Plusieurs séquences de virus AAV ont été isolées à partir de divers tissus porcins, et une analyse BLAST a confirmé une homologie élevée à faible avec des séquences de virus AAV connues d'origine différente. L'analyse de séquences a confirmé l'isolement d'au moins trois nouveaux isolats de virus AAV porcins qui ont été nommés AAVpo1, -po2, et -po3. Les nouveaux virus AAV dérivés de tissus porcins peuvent contribuer de façon significative à la production de nouvelles modalités cliniques préventives ou curatives acceptables pour être utilisées sur des humains.

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