Porcine b7-1 and antibodies thereto

Details Porcine b7-1 and antibodies thereto Porcine b7-1 and antibodies thereto

A - Human Necessities

61

K

A61K 38/22 (2006.01) A61K 39/395 (2006.01) A61K 47/00 (2006.01) C07H 21/04 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2361637

Soluble and transmembrane porcine B7-1 proteins, their amino acid sequences, nucleic acid sequences coding therefor, as well as antibodies reactive with the B7-1 proteins are disclosed. Methods of making the soluable and transmembrane porcine B7-1 DNA, cDNA, proteins, and antibodies, as well as, methods of using the B7-1 molecules and antibodies thereto, including use in the prevention and/or treatment of rejection of xenotransplants and treatment of inflammatory diseases, are described.

L'invention concerne des protéines porcines B7-1 transmembranaires et solubles, leurs séquences d'acide aminé, les séquences d'acide nucléique codant pour lesdites protéines porcines B7-1, ainsi que des anticorps qui réagissent contre les protéines B7-1. L'invention concerne des méthodes de production d'ADN de protéines porcines B7-1 transmembranaires et solubles, d'ADNc, de protéines, et d'anticorps, ainsi que des méthodes utilisant les molécules B7-1 et leurs anticorps, notamment pour prévenir et/ou traiter un rejet de xénotransplants, et pour traiter des maladies inflammatoires.

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