C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/34 (2006.01) A61K 39/295 (2006.01) C07K 14/01 (2006.01) C07K 14/205 (2006.01)
Patent
CA 2604705
The present invention is based on the discovery of novel species of the genus Helicobacter that are associated with gastroesophageal ulceration in pigs. In particular, a novel species, H. cerdo, has been used as a source of antigenic material for the development of vaccine for the treatment of the gastroesophageal disorders. Most advantageously, the novel Helicobacter and the porcine circoviruses associated with PMWS in pigs are useful for providing combination vaccines whereby immunogens derived from both types of pathogens may be codelivered to the tax get animal to stimulate the generation of protective antibodies and immunity. The invention, therefore, provides vaccines that are useful for the tratment of gastro esophageal ulceration and PMWS in porcines. The present invention includes, therefore, multivalent immunogenic compositions and vaccines, multivaccine kits, and combined immunization or vaccination methods which make it possible to use such combined immunization or vaccination programmes.
La présente invention repose sur la découverte de nouvelles espèces du genre Helicobacter qui sont associées à l'ulcération gastro-oesophagienne chez le porc. En particulier, une nouvelle espèce, H. cerdo, a été utilisé comme source de matière antigène pour la mise au point d'un vaccin pour traiter les troubles gastro-oesophagiens. Plus particulièrement, le nouvel Helicobacter et les circovirus porcins associés au syndrome de dépérissement multisystémique post-sevrage (PMWS) chez le porc, s'avèrent utiles pour des vaccins combinés, des immunogènes dérivés des deux types d'agents pathogènes pouvant être co-administrés à l'animal cible pour stimuler la production d'anticorps protecteurs et l'immunité. Ainsi, l'invention a pour objet des vaccins qui sont utiles pour traiter l'ulcération gastro-oesophagienne et le PMWS chez le porc. L'invention concerne ainsi des compositions et vaccins immunogènes polyvalents, des kits de plusieurs vaccins, et des procédés d'immunisation ou vaccination combinés qui rendent possible l'utilisation de programmes d'immunisation ou vaccination combinés.
Charreyre Catherine
Ellis John
Martinon Olivier Michel
Fetherstonhaugh & Co.
Merial Limited
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