C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) C12N 5/071 (2010.01) A01K 67/027 (2006.01) C12N 5/10 (2006.01) C12N 9/02 (2006.01) C12N 15/85 (2006.01) C12N 15/90 (2006.01)
Patent
CA 2528500
The present invention provides porcine CMP-N-Acetylneuraminic-Acid Hydroxylase (CMP-Neu5Ac hydroxylase) protein, cDNA, and genomic DNA regulatory sequences. Furthermore, the present invention includes porcine animals, tissues, and organs, as well as cells and cell lines derived from such animals, tissues, and organs, which lack expression of functional CMP-Neu5Ac hydroxylase. Such animals, tissues, organs, and cells can be used in research and in medical therapy, including in xenotransplantation, and in industrial livestock farming operations.
La présente invention concerne une protéine porcine de l'hydroxylase d'acide CMP-N-acétylneuraminique (hydroxylase de CMP-Neu5Ac), un ADNc et des séquences régulatrices d'ADN génomique. L'invention concerne en outre des animaux, des tissus et des organes porcins, ainsi que des cellules et des lignées cellulaires issues desdits animaux, tissus et organes, dépourvus d'expression de l'hydroxylase de CMP-Neu5Ac. Ces animaux, tissus, organes et cellules peuvent être utilisés dans les domaines de la recherche et du traitement médical, notamment dans le domaine de la xénotransplantation et dans des activités d'élevage de bétail industriel.
Mbm Intellectual Property Law Llp
University Of Pittsburgh
LandOfFree
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