C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/00 (2006.01)
Patent
CA 2565986
The present invention provides porcine Forssman synthetase (FSM snythase) (Globoside .alpha.-N-acetylgalactosaminyltransferase) protein, cDNA, and genomic DNA sequence. Furthermore, the present invention includes porcine animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which lack expression of functional FSM synthetase. Such animals, tissues, organs and cells can be used in research and in medical therapy, including in xenotransplantation. In addition, methods are provided to prepare organs, tissues, and cells lacking the porcine FSM synthetase gene for use in xenotransplantation.
La présente invention fournit une protéine de ligase de Forssman porcine (ligase FSM) (Globoside .alpha.-N-acetylgalactosaminyltransferase), de l'ADN complémentaire et une séquence ADN génomique. En outre, la présente invention comprend des organes, tissus, animaux porcins ainsi que des cellules et des lignées cellulaires dérivées de tels animaux, tissus et organes, manquant d'expression de ligase FSM fonctionnel. De tels animaux, tissus, organes et cellules peuvent être utilisés dans la recherche et la thérapie médicale, y compris dans la xénogreffe. En outre, des méthodes sont fournies pour préparer des organes, des tissus et des cellules manquant de gène de ligase FSM porcin pour utilisation dans la xénogreffe.
Mbm Intellectual Property Law Llp
University Of Pittsburgh Of The Commnonwealth System Of Higher E
LandOfFree
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