C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/70 (2006.01) C12N 7/00 (2006.01) C12N 7/02 (2006.01) C12N 7/04 (2006.01) C12N 7/08 (2006.01)
Patent
CA 2577801
A method of predicting the virulence of a new or uncharacterized PRRS virus isolate is provided wherein the isolate is injected into swine and allowed to replicate for a period of from about 3-15 days. During this period, the rate of virus growth and/or the magnitude of viremia is determined, and this data is compared with a corresponding growth rate and/or viremia magnitude of a PRRS virus isolate of known virulence, as a measure of the virulence of the new or uncharacterized isolate. Additionally, a method of selecting an isolate for inclusion in an immunogenic composition based on the predicted virulence is also provided, together with compositions incorporating attenuated forms of viruses predicted to be virulent.
L'invention concerne un procédé de prévision de la virulence d'un isolat nouveau ou non caractérisé du virus SDRP, l'isolat étant injecté dans un porc aux fins de réplication pendant environ 3-15 jours. On détermine alors le taux de croissance du virus et/ou l'amplitude de la virémie, puis les données correspondantes sont comparées aux mêmes données qui correspondent à un isolat de virus SRDP de virulence connue, permettant d'évaluer la virulence de l'isolat susmentionné. On décrit aussi, un procédé de sélection d'isolat aux fins d'introduction dans une composition immunogène, comte tenu de la virulence prévue, et des compositions incorporant des formes atténuées de virus prévus comme étant virulents.
Johnson Wesley
Roof Michael
Vaughn Eric
Boehringer Ingelheim Vetmedica Inc.
Fetherstonhaugh & Co.
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