C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/40 (2006.01) A61K 39/12 (2006.01) A61P 31/14 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12N 7/08 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2650236
Substantially avirulent forms of atypical porcine reproductive and respiratory syndrome (PRRS) virus and corresponding vaccines are provided which result from cell culture passaging of virulent forms of PRRS. The resultant avirulent atypical PRRS virus is useful as a vaccine in that PRRS specific antibody response is elicited by inoculation of host animals, thereby conferring effective immunity against both previously known strains of PRRS virus and newly isolated atypical PRRS virus strains. The preferred passaging technique ensures that the virus remains in a logarithmic growth phase substantially throughout the process, which minimizes the time required to achieve attenuation.
Burkhart Kelly
Gorcyca David E.
Lager Kelly
Mengeling William L.
Roof Mike
Boehringer Ingelheim Vetmedica Inc.
Gowling Lafleur Henderson Llp
United States Of America As Represented By The Secretary Of Agriculture
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