Pore forming peptides from geolycosa riogrande

Details Pore forming peptides from geolycosa riogrande Pore forming peptides from geolycosa riogrande

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 38/17 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2181592

Polypeptides isolated from the venom of the Geolycosa riogrande spider form pores in the plasma membrane of cells and are effective in mobilizing intracellular calcium ions in cells. These polypeptides are useful in such areas as drug delivery, cancer chemotherapy and immunotherapy, as well as in the physiological study of cells.

Des polypeptides isolés à partir du venin de l'araignée Geolycosa riogrande forment des pores dans la membrane plasmatique de cellules et permettent de mobiliser des ions calcium intracellulaires dans des cellules. Ces polypeptides s'utilisent dans des domaines tels que l'administration de médicaments, la chimiothérapie du cancer et l'immunothérapie, de même que dans l'étude physiologique des cellules.

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