A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/46 (2006.01) A61L 27/20 (2006.01) A61L 27/22 (2006.01) A61L 27/42 (2006.01) A61L 27/56 (2006.01)
Patent
CA 2691801
The present invention refers to a porous composite material, wherein at least one interdispersed biopolymer is present, with a calcium-phosphate mineral component comprising from 50 w/% to 95 w/% of .alpha.-tricalcium phosphate (.alpha.-TCP, .alpha.-Ca3 (PO4)2) and from 5 w/% to 50 w/% of octacalcium phosphate (OCP, Ca8H2(PO4)6-5H2O), to the total weight of the mineral component. Such combination of .alpha.-TCP and OCP allows an in vivo faster resorption rate and thereby a faster formation of new bone tissue having a low cristallinity mineral component with nanocrystal structure, features very similar to those of biological apatites. This porous composite material may find application as bone and/or osteal- chart ilagineous substitute (scaffold) and in producing tissue engineering devices.
L'invention porte sur un matériau composite poreux dans lequel est dispersé au moins un biopolymère, ledit composite comprenant un composant minéral de phosphates de calcium contenant : de 50 % à 95 % en poids de phosphate tricalcique a (a-TCP, a-Ca3 (PO4) 2) et de 5 % à 50 % en poids de phosphate octacalcique (OCP, Ca8H2(PO4)6-5H2O), du poids total du composant minéral. Une telle combinaison de a-TCP et de OCP permet une vitesse de résorption in vivo plus élevée et une formation plus rapide de nouveaux tissus osseux de structure nanocristalline et à faible cristallinité minérale, très similaire à celle des apatites biologiques. Ce matériau composite poreux peut avoir des applications en tant que substitut cartilagineux osseux ou ostéal (structure) et pour la production de dispositifs générateurs de tissus.
Bigi Adriana
Fini Milena
Giardino Roberto
Panzavolta Silvia
Alma Mater Studiorum-Universita' Di Bologna
Istituto Ortopedico Rizzoli
Oyen Wiggs Green & Mutala Llp
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