C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/17.08, 195/3
C12N 11/08 (2006.01) C07K 17/08 (2006.01)
Patent
CA 2024196
ABSTRACT OF THE DISCLOSURE The present invention relates to a porous microbead having a size range between 100µ and 10mm and at least one biological particulate immobilized therein, said immobilized particulate being selected from the group consisting of microorganism, cell, a suspension of enzymes and a suspension of proteins, wherein said microbead is further characterized by having pores therethrough and wherein the average size of said pores ranges between 30.ANG. and 1µ and allows the release of any macromolecule derived from said immobilized particulate to the outside of said microbead and the exchange of any other macromolecule between the outside and the inside of said microbead. There is also provided a preferred embodiment wherein said particulate is the microorganism P. pictorum which possesses the ability to breakdown cholesterol in a macromolecular cholesterol- lipoprotein complex, and wherein said cholesterol containing liquid is flowed through said microbead thereby causing the cholesterol of the cholesterol-lipoprotein complex which penetrate into said microbead from the outside medium of said microbead to be degraded by said immobilized microorganism or components thereof such as bacterial extracts and releasing said lipoprotein to the outside of said microbead.
Chang Thomas M. S.
Garofalo Flavio A.
Chang Thomas M. S.
Garofalo Flavio A.
Goudreau Gage Dubuc
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