Porous polymeric prostheses and methods for making same

A - Human Necessities – 61 – L

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A61L 27/56 (2006.01) A61F 2/00 (2006.01) A61F 2/04 (2006.01) A61K 9/14 (2006.01) A61L 27/00 (2006.01) A61L 27/14 (2006.01) B29C 65/00 (2006.01) B29D 22/00 (2006.01) B29D 23/00 (2006.01) B32B 1/08 (2006.01) B65D 1/00 (2006.01) C08F 2/00 (2006.01) C08F 283/04 (2006.01) C08J 3/00 (2006.01) C08J 9/00 (2006.01) C08J 9/28 (2006.01) C08J 11/00 (2006.01) C08K 3/00 (2006.01) C08L 1/00 (2006.01) F16L 1/00 (2006.01) C08L 101/16 (2006.01)

Patent

CA 2465897

Porous polymers having a plurality of openings or chambers that are highly convoluted, with each chamber being defined by multiple, thin, flat partitions are produced by a new gel enhanced phase separation techinque. In a preferred embodiment, a second solven t is added to a ploymer solution, the second solvent causing the solution to gel. The gel can then be shaped as needed. Subsequent solvent extraction leaves the porous polymeric body of defined shape. The porous polymers have utility as medical protheses, t he porosity permitting ingrowth of neighboring tissue. The present technique also enhances shape-making capability, for example, of bifurcated vascular grafts, which feature a common entrance re gion but two or more exit regions.

L'invention concerne des polymères poreux présentant une pluralité d'ouvertures ou de chambres hautement enroulées, chaque chambre étant définie par de multiples cloisons plates et minces, et lesdits polymères étant obtenus par une nouvelle technique de séparation de phase activée par gel. Dans un mode de réalisation préféré, un second solvant est ajouté à une solution polymérique, permettant ainsi d'obtenir une solution sous forme de gel. Le gel peut prendre la forme nécessaire. L'extraction ultérieure du solvant permet d'obtenir un corps polymérique poreux de forme définie. Les polymères poreux sont utilisés dans les prothèses médicales, la porosité permettant la croissance interne de tissus adjacents. La technique de l'invention permet également d'améliorer la capacité de mise en forme, par exemple, de greffes vasculaires bifurquées, comprenant une région d'entrée commune mais deux ou plusieurs régions de sortie.

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