Porous structures with modified biodegradation kinetics

Details Porous structures with modified biodegradation kinetics Porous structures with modified biodegradation kinetics

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2749467

Biodegradation kinetics of biodegradable porous objects, such as porous silicon objects, can be controlled by a molecular weight of polymer chains, such as polyethylene glycol chains, disposed on an outer surface of the object. Provided are biodegradable porous objects, which have their biodegradation kinetics controlled by a molecular weight of the disposed polymer chains. Also provided are methods of making such biodegradable porous objects as well as methods of using such biodegradable porous objects for delivery of active agents, such as therapeutic agents and/or imaging agents.

Selon l'invention, la cinétique de biodégradation d'objets poreux biodégradables, tels que des objets en silicium poreux, peut être commandée par une masse moléculaire de chaînes polymères, telles que des chaînes de polyéthylène glycol, disposées sur une surface extérieure de l'objet. L'invention porte sur des objets poreux biodégradables, ayant leur cinétique de biodégradation commandée par la masse moléculaire des chaînes polymères disposées. L'invention porte également sur des procédés de fabrication de tels objets poreux biodégradables ainsi que sur des procédés d'utilisation de tels objets poreux biodégradables pour l'administration d'agents actifs, tels que des agents thérapeutiques et/ou des agents d'imagerie.

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