Porous tablets as carriers for liquid formulations

A - Human Necessities – 61 – K

Patent

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A61K 9/20 (2006.01)

Patent

CA 2572180

A novel tablet product that in an easy, flexible and reproducible manner can be loaded with a relatively high amount of a pharmaceutically acceptable liquid formulation e.g. carrying a therapeutically, prophylactically and/or diagnostically active substance. The novel loadable tablet product may be produced in large-scale batches and stored until use and each batch or sub- batch may be loaded with the same or different pharmaceutically acceptable liquid formulations and/or active substances. A loadable tablet according to the invention has a porosity of 30% v/v or more. The invention also provides tablets that have been loaded with such a liquid formulation as well as a method for the preparation thereof.

L'invention concerne un nouveau produit de comprimé, qui de manière facile, souple et reproductible peut être chargé dans une quantité relativement élevée d'une formulation liquide pharmaceutiquement acceptable supportant, par exemple, une substance thérapeutique, prophylactique et/ou diagnostique active. Ce nouveau produit de comprimé chargeable peut être produit par lots à grande échelle et stocké jusqu'à son utilisation, chaque lot ou sous-lot pouvant être chargé à l'aide de formulations liquides pharmaceutiquement acceptables et/ou de substances actives identiques ou différentes. Un comprimé chargeable selon l'invention possède une porosité égale à 30 % v/v ou plus. L'invention concerne également des comprimés chargés à l'aide desdites formulations liquides ainsi qu'un procédé de préparation.

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