Porphyrin derivatives

Details Porphyrin derivatives Porphyrin derivatives

C - Chemistry, Metallurgy

07

D

260/237.2

C07D 487/22 (2006.01)

Patent

CA 1315780

Abstract: Porphyrin derivatives Novel porphyrin derivatives of -the general formula: Image wherein R1 each independently denotes a hydrogen, a C1-C4 alkyl group or an ethenyl group, and R2 each independently denotes COZ(CmH2m)Q, COZCH(CmH2mQ)2, -CH2-Q [wherein Z is O, S or NH, m is an interger of 1 to 23, and Q is a di-(C1-C4 alkyl)amino group or tri-(C1-C4 alkyl)ammonium halide group] or Image (wherein X is a halogen); or R1 each independently denotes -C2H4-Q (wherein Q is the same as defined above), -C2H4- Image or Image (wherein X is the same as defined above), and R2 each inde- pendently denotes a carboxyl group or a C1-C4 alkoxycarbonyl group, and the production thereof are described. The quater- nary ammonium salt type of the above compounds exhibit affinity and photosensitizing activity for cancer cells and can be employed for diagnosing and treating cancer under irradiation of laser light.

527443

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