Porphyrin derivatives

Details Porphyrin derivatives Porphyrin derivatives

C - Chemistry, Metallurgy

07

D

C07D 487/22 (2006.01) A61K 41/00 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2513133

The present invention is related to novel photopyrin compounds and the pharmaceutically acceptable salt thereof useful as an anticancer or photodynamic diagnostic agent by way of reproducing singlet state oxygen radical and the inventive compounds have superior advantages such as excellent photon yield to produce singlet oxygen, good physical stability and potent cell cytotoxicity to conventional photosensitizer. The present invention also provides a pharmaceutical composition comprising a novel photopyrin compound of formula (I) to (VII) or a pharmaceutically acceptable salt thereof as an active ingredient for preventing or treating various cancers such as stomach cancer, liver cancer, lung cancer, cervical cancer and breast cancer in human or mammal together with a pharmaceutically acceptable carrier.

L'invention concerne des composés de photopyrine, y compris leurs sels pharmaceutiquement acceptables, utiles comme anticancéreux ou agents de diagnostic photodynamiques par la reproduction de radical d'oxygène à l'état de singulet. Les composés décrits offrent des avantages supérieurs, du type excellent rendement photonique pour la production d'oxygène à l'état de singulet, bonne stabilité physique, et cytotoxicité cellulaire puissante par rapport à un photosensibilisant classique. L'invention concerne également une composition pharmaceutique comprenant un composé de photopyrine de formule (I) à (VII), y compris un sel pharmaceutiquement acceptable correspondant, comme principe actif pour la prévention ou le traitement de différents cancers (par exemple, estomac, foie, poumon, utérus, sein) chez l'homme ou autre mammifère, et un vecteur pharmaceutiquement acceptable.

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