Porphyrin derivatives, and their production and use

Details Porphyrin derivatives, and their production and use Porphyrin derivatives, and their production and use

C - Chemistry, Metallurgy

07

D

167/47, 260/237.

C07D 487/22 (2006.01) A61K 49/02 (1990.01)

Patent

CA 1311239

- 1 - Abstract: A condensation product of (a) a porphyrin compound of the formula: (I) Image wherein R1 and R2 are each -CH=CH2, -CH2CH3, -CH(O-lower alkanoyl)CH3, -CH(OR)CH3 or -CH(O-lower alkylene-OR)CH3; R3 is -H, -COOH, -COO-lower alkyl, -COO-lower alkylene-OR or -COO-lower alkylene-OOC-Z; R4 is -H, -lower alkyl or -lower alkylene-OR; R is -H or -lower alkyl; Z is a residue of the compound of the formula (I) excluding R3 therefrom; A is -CH2- or -CO-; and the dotted line from the gamma- position indicates no bonding or a single direct bond; and the dotted line between the 7- and 8-positions indicates the presence of a single bond or a double bond; at least one of R1, R2, R3 and R4 being a group containing R representing -H when R3 is other than -COOH - 2 - and R1 being capable of representing l-iodoethyl in addition to said meanings when R3 is -COO-lower alkylene- OOC-Z, with (b) a polyfunctional carboxyl compound, which shows a high accumulation in the locus of cancer with quick excretion from normal tissues.

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