Porphyromonas gingivalis polypeptides useful in the...

C - Chemistry – Metallurgy – 07 – K

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C07K 14/195 (2006.01) A61K 38/16 (2006.01) A61K 39/02 (2006.01) A61K 39/40 (2006.01) A61P 1/02 (2006.01) C07K 16/12 (2006.01) C12N 15/31 (2006.01)

Patent

CA 2652957

The invention is directed to vaccine compositions and methods based on P. gingivalis proteins identified to be regulated by haem availability that can be used in the prevention and treatment of periodontal disease. In particular, two specific internalin-like P. gingivalis proteins, namely PG0350 and PG1374 involved in the internalization of P. gingivalis by host cells, the hypothetical protein, PG1019 purported to be a cell surface lipoprotein and the alkyl hydroperoxide reductase protein, PG0618 have been identified as useful targets for the prevention and treatment of periodontal disease.

L'invention concerne des compositions de vaccin et des procédés basés sur des protéines de P. gingivalis identifiées comme étant régulées par la disponibilité de l'hème qui peuvent être utilisées dans la prévention et le traitement de la parodontolyse. En particulier, deux protéines spécifiques de P.gingivalis analogues de l'internaline, à savoir PG0350 et PG1374, impliquées dans l'internalisation de P. gingivalis par des cellules hôtes, la protéine hypothétique, PG1019, présentée comme étant une lipoprotéine de surface cellulaire et la protéine alkyl hydroperoxyde réductase, PG0618, ont été identifiées comme cibles utiles pour la prévention et le traitement de la parodontolyse.

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