Portulaca oleracea and tumor cell growth

Details Portulaca oleracea and tumor cell growth Portulaca oleracea and tumor cell growth

A - Human Necessities

61

K

A61K 36/36 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2191923

Portulaca oleracea has been used throughout history for many different medicinal purposes. This invention is directed to the novel use of P. oleracea for the treatment of cancer. More specifically it is disclosed that P. oleracea has a specific and distinct effect on the inhibition and/or suppression of gastric tumor cell growth in vitro and in vivo. An aqueous extract of P. oleracea showed a tumoricidal activity against KATO III (human gastric carcinoma cell line) and COLO 320 HSR cells (human colon adenoma cell line) in a dose-dependent and time-dependent manner, but not against the non-tumorous cell lines, L929 (murine lung connective tissue) and WI38 (human lung diploid cell) cells. Subcutaneous injection of six week old CD1nude mice with COLO 320 HSR cells and subsequently Portulaca oleracea extract showed a clear inhibition of tumor growth as compared to the control nude mice which received only COLO 320 HSR cells.

Historiquement, Portulaca oleracea a eu de nombreuses applications médicales différentes. La présente invention a trait à l'usage inédit de P. oleracea pour le traitement du cancer. Plus précisément, il est révélé que P. oleracea a un effet spécifique et distinct sur l'inhibition et/ou la suppression de la croissance des cellules tumorales gastriques in vitro et in vivo. Un extrait aqueux de P. oleracea a montré une activité tumoricide contre KATO III (lignée cellulaire de carcinome gastrique humain) et les cellules COLO 320 HSR (lignée cellulaire de l'adénome du côlon humain) et cette activité est fonction de la dose et du temps, mais n'a pas d'activité contre les lignées cellulaires non tumorales, les cellules L929 (tissu conjonctif pulmonaire murin) et W138 (cellules diploïdes pulmonaires humaines). L'injection sous-cutanée à des souris nudes CD1 âgées de 6 semaines de cellules COLO 320 HSR suivie de l'injection d'une extrait de Portulaca oleracea a montré une nette inhibition de la croissance tumorale comparativement aux souris nudes témoins qui ont reçu uniquement les cellules COLO 320 HSR.

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