Positive modulator of bone morphogenic protein-2

Details Positive modulator of bone morphogenic protein-2 Positive modulator of bone morphogenic protein-2

C - Chemistry, Metallurgy

07

K

C07K 5/00 (2006.01) A61K 38/00 (2006.01) C07K 14/00 (2006.01)

Patent

CA 2555583

Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non- growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.

L'invention concerne des composés de formule (I) et de formule (II) décrits dans la description. Ces composés sont des modulateurs de l'activité d'une protéine morphogénique osseuse. Les composés de l'invention sont des peptides synthétiques présentant une zone de liaison d'héparine à facteur de non croissance, un élément de liaison et des séquences se liant spécifiquement à un récepteur de protéine morphogénique osseuse. L'invention concerne les utilisations de ces composés pour traiter des lésions osseuses, une maladie articulatoire dégénérative et pour améliorer une formation osseuse.

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