Positive modulators of nicotinic acetylcholine receptors

Details Positive modulators of nicotinic acetylcholine receptors Positive modulators of nicotinic acetylcholine receptors

A - Human Necessities

61

K

A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61P 25/18 (2006.01) A61P 25/26 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2524019

Compounds of Formula (I) or Formula (II) wherein R1, X and Ar are as described in the specification, pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially for treatment of conditions associated with reductions in nicotinic transmission.

L'invention concerne des composés représentés par la formule I ou la formule II dans lesquelles R?1¿, X et Ar sont tels que décrits dans les spécifications, des sels acceptables d'un point de vue pharmaceutique de ceux-ci, des procédés de préparation de ceux-ci, des compositions pharmaceutiques les contenant et leur utilisation thérapeutique, en particulier dans le traitement d'états associés aux réductions de transmission nicotinique.

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