Positron emission tomography imaging method

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 475/04 (2006.01) A61K 51/04 (2006.01) G01T 1/164 (2006.01)

Patent

CA 2592302

The invention relates to compositions and methods to diagnose/monitor, using positron emission tomography, pathogenic disease states wherein the pathogenic cells uniquely express, preferentially express, or overexpress vitamin receptors. In an illustrative embodiment, vitamins, or analogs thereof, conjugated to a radiophore are used to diagnose/monitor disease states extra- corporeally using positron emission tomography. The disease states that can be diagnosed/monitored in accordance with the invention are cancer and disease states involving activated macrophages, such as disease states involving an inflammatory response.

L'invention concerne des compositions et des procédés de diagnostic/surveillance, mettant en oeuvre la tomographie d'émission de positrons, d'états de maladies pathogènes dans lesquels les cellules pathogènes expriment uniquement, de préférence, expriment ou surexpriment des récepteurs des vitamines. Dans un mode de réalisation, des vitamines ou des analogues de celles-ci conjuguées à un radiophore sont utilisées pour diagnostiquer/surveiller des états de maladies de manière extracorporelle, au moyen de la tomographie par émission de positrons. Les états de maladies pouvant être diagnostiqués/surveillés selon l'invention sont : le cancer et des états de maladies impliquant des macrophages activés, tels que des états de maladies impliquant une réponse inflammatoire.

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