Post-translational modification of recombinant proteins...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/82 (2006.01) A01H 5/00 (2006.01) C12N 9/10 (2006.01)

Patent

CA 2388432

The present invention is directed to methods for producing a post- translationally modified heterologous polypeptide in a plant host system by altering the natural post-translational modification abilities of that plant host system. In another aspect of this method, altering the natural post- translational modifications is done by transforming the plant host system with one or more nucleic acid sequences encoding a post-translational modification enzyme.

L'invention concerne un procédé relatif à la production de protéines ou de polypeptides par le biais de plantes ou cellules de plantes manipulées génétiquement, ainsi que des plantes ou cellules de plantes manipulées génétiquement proprement dites (y compris les parties de ces plantes manipulées), le matériau de protéine hétérologue (par exemple, protéine, polypeptide et autre) que l'on produit à l'aide desdites plantes ou cellules de plantes manipulées, et enfin les polynucléotides de recombinaison (ADN ou ARN) utilisés pour la manipulation génétique.

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