C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) A61P 43/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2492536
A protein A binding to the N-methyl-D-aspartic acid (NMDA) receptor and another protein B interacting with the protein A are provided. Based on the fact that these proteins remarkably promote the signal transfer of the NMDA receptor, controllers (inhibitors or promoters) for the expression and/or functions of these proteins and a method of controlling the same are provided. Thus, it becomes possible to clarify diseases caused by failures in the NMDA receptor signal transfer or memory regeneration, for example, neurodegenerative diseases such as Alzheimer~s disease, Parkinson~s disease and polyglutamine disease as well as to prevent, ameliorate or treat these diseases.
L'invention concerne une protéine A se liant à un récepteur d'acide N-méthyl-D-aspartique (NMDA) et une autre protéine B interagissant avec la protéine A. Etant donné que ces protéines favorisent sensiblement le transfert de signal du récepteur NMDA, des régulateurs (inhibiteurs ou promoteurs) de l'expression et/ou des fonctions de ces protéines et un procédé destiné à réguler ceux-ci sont fournis. Ainsi, il est possible de clarifier des maladies entraînées par des défaillances dans le transfert de signal du récepteur NMDA ou dans la régénération de mémoire, par exemple, des maladies neurodégénératives telles que la maladie d'Alzheimer, la maladie de Parkinson et la maladie due à la polyglutamine. Il est, en outre, possible de prévenir, d'améliorer ou de traiter ces maladies.
Arai Yasuko
Nagase Takahiro
Ohara Osamu
Ohishi Michio
Yokota Hiroshi
Daiichi Pharmaceutical Co. Ltd.
Kazusa Dna Research Institute Foundation
Moffat & Co.
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