Postsynaptically targeted chemodenervation agents and their...

Details Postsynaptically targeted chemodenervation agents and their... Postsynaptically targeted chemodenervation agents and their...

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01)

Patent

CA 2754352

Improved chemodenervation agents are provided comprising polypeptide .alpha.- neurotoxins having high binding specificity and selectivity for the human muscular .alpha.1 nAChR instead of the human neuronal .alpha.7 nAChR, along with pharmaceutical compositions and methods of use.

Linvention concerne des agents de chimiodénervation améliorés qui comprennent des a-neurotoxines de polypeptides ayant une spécificité et une sélectivité de liaison élevée pour le a1 nAChR musculaire humain à la place du a7 nAChR neuronal humain, ainsi que des compositions pharmaceutiques et des procédés dutilisation.

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