Potassium channel inhibitors

Details Potassium channel inhibitors Potassium channel inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/56 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) A61P 9/06 (2006.01) C07D 213/40 (2006.01) C07D 233/54 (2006.01) C07D 239/26 (2006.01) C07D 239/34 (2006.01) C07D 239/42 (2006.01) C07D 241/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2416870

Compounds which are useful as potassium channel inhibitors and which because of their slow off-rates are especially useful for the treatment of cardiac arrhythmias are described: (I) wherein R1-R11, A, B, D and G are as defined in the claims.

La présente invention concerne des composés représentés par la formule générale (I) et convenant généralement comme inhibiteurs du canal potassium. En raison de leur lenteur de déplétion, ces composés conviennent plus particulièrement pour le traitement des arythmies cardiaques. Dans la formule générale (I), les groupes R?1¿-R?11¿, A, B, D et G sont tels que définis par les revendications.

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