Potassium channel inhibitors

Details Potassium channel inhibitors Potassium channel inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/75 (2006.01) A61K 31/18 (2006.01) A61K 31/44 (2006.01) C07C 311/20 (2006.01) C07D 213/38 (2006.01) C07D 213/61 (2006.01) C07D 213/74 (2006.01) C07D 213/80 (2006.01) C07D 213/82 (2006.01) C07D 233/54 (2006.01) C07D 239/42 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2432783

Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders of the formula (I) are described, wherein A, B and D are selected from a substituted carbon atom, a nitrogen atom or N.fwdarw.O, wherein at least one of A, B and D is substituted carbon atom and at most only one of A, B and D is N.fwdarw.O; E is hydrogen, or alkyl; G is hydrogen, or alkyl; or E and G taken together form a bond (site of unsaturation); R1 is selected from hydrogen, alkyl, carbocycloalkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl and (heteroaryl)alkyl; R2 is selected from alkyl, carbocycloalkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl and (heteroaryl)alkyl; R3 is selected from hydrogen (H), alkyl, carbocycloalkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, (heteroaryl)alkyl, aminoalkyl; substituted aminoalkyl, carboxyalkyl, alkoxyalkanoyl, aminoalkanoyl, substituted aminoalkanoyl, alkanoylaminoalkyl, alkanoyl(substituted amido)alkyl, aroylamidoalkyl, aroyl(substituted amido)alkyl, heterocyclocarbonylamidoalkyl, heterocyclocarbonyl(substituted amido)alkyl, heteroaroylamidoalkyl, and heteroaroyl(substituted amido)alkyl; R4 is selected from alkyl, carbocycloalkyl, aryl, (aryl)alkyl, heteroaryl and heterocyclo; R5 and R6 are each independently selected from hydrogen, fluoro and alkyl, or R5 and R6 taken together, along with the carbon atom to which they are both attached, form a 3-membered to 7-membered carbocyclic, or heterocyclic ring; R7 is independently selected from hydrogen, alkyl, hydroxy, alkoxy, amino, substituted amino, nitro, cyano, halo, carboxy, alkoxycarbonyl, aminocarbonyl, substituted aminocarbonyl and n is 1, 2 or 3; Z is selected from hydrogen, alkyl, hydroxy, SH, alkoxy, aryloxy, alkylthio, amino, substituted amino, alkoxycarbonyl, alkanoylamido, aroylamido, heterocyclocarbonylamido, heteroaroylamido, alkanoyl(alkylsubstituted)amido, aroyl(alkylsubstituted)amido, heteroaroyl(alkylsubstituted)amido and heterocyclocarbonyl(alkyl substituted)amido.

Composés utiles en tant qu'inhibiteurs du canal potassique et particulièrement efficaces pour traiter des arythmies cardiaques et des maladies prolifératives cellulaires.

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